Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
Journal website http://www.journalmc.org

Case Report

Volume 5, Number 1, January 2014, pages 26-30

Alveolar Rhabdomyosarcoma of the Paranasal Cavity in an Adult Woman

Figures

Figure 1.
Figure 1. CT scan reveals a right ethmoidal sinus lesion (A), 30 mm in diameter, extending to the homolateral maxillary sinus and medial turbinate, and infiltrating the right orbital cavity (B).
Figure 2.
Figure 2. Histological examination of the biopsy shows a submucosal infiltrative lesion composed of sheets of small cells (A, hematoxylin and eosin, original magnification × 200) displaying round hyperchromatic nuclei with nucleoli, scant eosinophilic cytoplasm and brisk mitotic activity (B, hematoxylin and eosin, original magnification × 400). At immunohistochemistry, the neoplastic cells show a diffuse cytoplasmic positivity for CD56 (C, original magnification × 630) and desmin (D, original magnification × 400) and diffuse nuclear positivity for myogenin (E, original magnification × 400).

Table

Table 1. Details on Antibodies Used for the Immunohistochemical Study
 
AntibodyCloneSourceDilutionPretreatment
GFAP6F2Dako1:50Microwave
Chromogranin ADAK-A3Dako1:100Microwave
Vimentin3B4VentanaNoPressure cooker
DesminD33Dako1:50Microwave
CD56123C3DakoNoMicrowave
CK20K20.8DakoNoMicrowave
CK7OV-TL 12/30Dako1:50Microwave
CytokeratinAE1/AE3Dako1:50Pressure cooker
S-100 proteinPolyclonalDako1:400Microwave
HMB45HMB45Novocastra1:30Microwave
MART1A103Dako1:25Microwave
SynaptophysinSY38DakoNoMicrowave
EMAGP1.4NovocastraNoMicrowave
CD452B11 + PD7/26DakoNoMicrowave
MyogeninF5DDakoNoMicrowave
EBV-LMP1CS.1-4DakoNo diluitionMicrowave
MyeloperoxidasePolyclonalDako1:300Microwave
MYOD15.8ADako1:50Pressure cooker