Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 5, Number 4, April 2014, pages 241-244

Composite Mantle Cell Lymphoma and “Gray Zone” Lymphoma in Two Different Anatomical Locations


Figure 1.
Figure 1. Sagittal post-contrast T1-weighted image of the thoracic spine reveals a lesion in the posterior (increased signal intensity) epidural region compressing the cord (a). Sagittal T2-weighted image of the thoracic spine at the same level depicts the same lesion in the posterior epidural region with low signal intensity (b).
Figure 2.
Figure 2. Neoplastic mantle cells and RS-like cells (a). Mantle cells positive to cyclinD1 (b) and RS cells immunoreactive to CD30 (c) and CD15 (d). Oct2 strong positivity of MCL and HRS cells (e). FISH method with IGH (red) and BCL1 (or CCND1) (green) gene probes revealing IGH/CCND1 gene fusion (arrows) (f). (a: HE, × 400; b, e: IHC, × 200; c, d: IHC, × 100).