J Med Cases

Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc

Journal website http://www.journalmc.org

Case Report

Volume 5, Number 4, April 2014, pages 227-231

Transmission of Hepatitis C Virus From a Mother to a Child Carrying IL28B Heterozygote rs8099917 Among Three Brothers: A Long-Term Follow-Up

Figures

Figure 1. Clinical course and serum alanine aminotransferase (ALT) levels in the mother with chronic HCV genotype 2b infection. Positivity and negativity for serum HCV RNA are represented as plus (+) and minus (-), respectively. PegIFN/RBV: pegylated interferon plus ribavirin treatment.

Figure 2. Long-term follow-up of serum alanine aminotransferase (ALT) levels in the second child with maternal HCV genotype 2b infection. Positivity for serum HCV RNA is represented as plus (+).

Table

**Table 1.** Characteristics of Children Born From the HCV-Infected Mother
	First child	Second child	Third child
NSD: normal spontaneous delivery; n.t.: not tested; CI: cutoff index. *This assay was done using the preserved sample. HCV RNA was measured by branched DNA assay, real time PCR, *qualitative PCR.
Sex	Male	Male	Male
Delivery	NSD (39 weeks)	NSD (40 weeks)	NSD (40 weeks)
Body weight at birth	3,364 g	3,492 g	3,400 g
HCV RNA in mother’s serum before birth	8.2 Meq/mL*	6.0 log IU/mL**	40.0 Meq/mL*
Anti-HCV antibody in umbilical blood	Positive (CI > 5.0)	Positive (CI > 5.0)	Positive (CI > 5.0)
HCV RNA in umbilical blood	n.t.	< 0.5 Meq/mL*	n.t.
Anti-HCV antibody in serum after birth	Negative	Positive (CI > 5.0)	Negative
HCV RNA in serum after birth	Negative***	Positive***	Negative***
Persistent HCV viremia (period)	Not applicable	15 years	Not applicable
IL28B polymorphism (rs8099917)	TG	TG	TT
IFNL4 polymorphism (ss469415590)	ΔG/TT	ΔG/TT	TT/TT