Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 5, Number 4, April 2014, pages 227-231

Transmission of Hepatitis C Virus From a Mother to a Child Carrying IL28B Heterozygote rs8099917 Among Three Brothers: A Long-Term Follow-Up


Figure 1.
Figure 1. Clinical course and serum alanine aminotransferase (ALT) levels in the mother with chronic HCV genotype 2b infection. Positivity and negativity for serum HCV RNA are represented as plus (+) and minus (-), respectively. PegIFN/RBV: pegylated interferon plus ribavirin treatment.
Figure 2.
Figure 2. Long-term follow-up of serum alanine aminotransferase (ALT) levels in the second child with maternal HCV genotype 2b infection. Positivity for serum HCV RNA is represented as plus (+).


Table 1. Characteristics of Children Born From the HCV-Infected Mother
First childSecond childThird child
NSD: normal spontaneous delivery; n.t.: not tested; CI: cutoff index. **This assay was done using the preserved sample. HCV RNA was measured by *branched DNA assay, **real time PCR, ***qualitative PCR.
DeliveryNSD (39 weeks)NSD (40 weeks)NSD (40 weeks)
Body weight at birth3,364 g3,492 g3,400 g
HCV RNA in mother’s serum before birth8.2 Meq/mL*6.0 log IU/mL**40.0 Meq/mL*
Anti-HCV antibody in umbilical bloodPositive (CI > 5.0)Positive (CI > 5.0)Positive (CI > 5.0)
HCV RNA in umbilical bloodn.t.< 0.5 Meq/mL*n.t.
Anti-HCV antibody in serum after birthNegativePositive (CI > 5.0)Negative
HCV RNA in serum after birthNegative***Positive***Negative***
Persistent HCV viremia (period)Not applicable15 yearsNot applicable
IL28B polymorphism (rs8099917)TGTGTT
IFNL4 polymorphism (ss469415590)ΔG/TTΔG/TTTT/TT