J Med Cases

Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc

Journal website http://www.journalmc.org

Case Report

Volume 5, Number 7, July 2014, pages 413-416

Silicone Breast Implants as Predisposing Factor for Non-Hodgkin’s Lymphoma: An Additional Facet of Auto-Inflammatory Syndrome Induced by Adjuvant

Figure

Figure 1. Abdominal CT scan with intravenous contrast injection. Para-aortic lymphadenopathy (black arrows) and left retroperitoneal and mesenteric root soft tissue infiltration (white arrows). Bladder wall thickening (curved arrow) and ascites seen at upper abdomen. (A) Axial slice at mid-abdomen. (B) Coronal image.

Table

**Table 1.** Suggested Criteria for the Diagnosis of “ASIA”
ASIA: autoimmune (auto-inflammatory) syndrome induced by adjuvants; HLA: human leukocyte antigen; MS: multiple sclerosis; SSc: systemic sclerosis.
Major criteria	Exposure to an external stimuli (infection, vaccine, silicone, adjuvant) prior to clinical manifestations.
	The appearance of “typical” clinical manifestations:
	Myalgia, myositis or muscle weakness
	Arthralgia and/or arthritis
	Chronic fatigue, un-refreshing sleep or sleep disturbances
	Neurological manifestations (especially associated with demyelination)
	Cognitive impairment, memory loss
	Pyrexia, dry mouth
	Removal of inciting agent induces improvement
	Typical biopsy of involved organs
Minor criteria	The appearance of autoantibodies or antibodies directed at the suspected adjuvant
	Other clinical manifestations (i.e. irritable bowel syn.)
	Specific HLA (i.e. HLA DRB1, HLA DQB1)
	Evolvement of an autoimmune disease (i.e. MS, SSc).