Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 2, Number 4, August 2011, pages 143-146

Follicular Dendritic Cell Sarcoma Arising in Hyaline-Vascular Castleman Disease of Mediastinum: A Case Report


Figure 1.
Figure 1. (A) In computed tomography, a huge lobulated solid mass is seen in the posterior mediastinum. (B) Grossly, the resected tumor is solid, vaguely nodular and tan to grayish cut surface. Adjacent enlarged lymph nodes are included.
Figure 2.
Figure 2. (A) The non-neoplastic lymphoid follicles show depletion of germinal center lymphocytes with increased FDCs and are penetrated by small capillaries. (B) Conglomerated lymph nodes are mostly replaced with neoplastic spindle cells arranged in fascicles. (C) The tumor cells show storiform arrangement that have indistinct cell borders and eosinophilic cytoplasm. Small lymphocytes were splinkled throughout the tumor. (D) Immunohistochemically, the tumor cells demonstrate strong cytoplasmic expression for CD21. Original magnification: A, 40 X; B, 100 X; C, 200 X; D, 200 X.