Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 7, Number 11, November 2016, pages 484-487


Primary Lung Adenocarcinoma With Trophoblastic Differentiation and Usage of Gefitinib for Postoperative Recurrence: Report of a Case With a Review of the Literature

Figures

Figure 1.
Figure 1. Preoperative chest X-ray showing a 2.5-cm round shadow in the left lung (a). CT revealed spicula and pleural indentation in S6 (b).
Figure 2.
Figure 2. Pathological examination demonstrated mixed adenocarcinoma with trophoblastic differentiation (a), and acinar-type non-mucous bronchioloalveolar carcinoma (b).
Figure 3.
Figure 3. MRI in June 2012 revealed metastases in the right ovary and uterus (arrowhead) (a). Necropsy of the ovary metastasis demonstrated adenocarcinoma accompanied by trophoblastic differentiation (b).

Table

Table 1. The Cases of Lung Carcinoma With Trophoblastic Differentiation or Choriocarcinoma of the Lung
 
YearAgeGenderTNMStageOperative procedureChemotherapy regimenCombined cancerObservation period (months)Cause of death
F: female; M: male; NA: not available; PN: pneumonectomy; LB: lobectomy; WR: wedge resection; ND: no description; 5FU: 5-flourouracil; CTX: cyclophosphamide; PVP: cisplatin and etoposide; MA-CO: methotrexate, actinomycin D/oncovin, cyclophosphamide; PE: etoposide and cisplatin; MAC: methotrexate/leucovorin, actinomycin-D, and cyclophosphamide or chlorambucil; PACE: cisplatin, adriamycin and cytoxan; VPV: bleomycin by vinblastine; EMA: etoposide and cisplatin/etoposide, methotrexate, and actinomycin D; BOMP-EPI: bleomycin, vincristine, methotrexate, platinum/etoposide, platinum, ifosfamide; BEP: bleomycin, etoposide, cisplatin; CHAMOCA: cyclophosphamide, hydroxyurea, actinomycin D, methotrexate, doxorubicin, melphalan and vincristine; MTX: methotrexate; UD: unknown details; NBC: nothing but choriocarcinoma; GCC: giant cell carcinoma; Sm: small cell carcinoma; Ad: adenocarcinoma; Sq: squamous cell carcinoma; La: large cell carcinoma; UDC: undifferentiated carcinoma; TR: treatment-related death; TD: tumor death.
1952NAF4NA1bIVPNNDND0TR
195429F32NANAPNNDNBC3TD
197745MNANANANA-NDGCC5TD
197757MNA3NANA-NDGCC12TD
197963MNA3NANA-5FU + CTXSm2TD
198027MNA00NALBPVPNBC4Alive
198267M3NANANALBNDNBC36Alive
198322F3NA1bIV-NDND0TD
198534F2a00IBLBUDNBC6Alive
198760F320IIIAPNNDND0TD
198821FNANA1bIV-MA-CONDNATD
198951M321bIV-NDNon-Ad non-Sq0TD
198937M320IIIAPNPELa15TD
199068M3NA0IIB-IIIBLBMAC, PE, PACELa15Alive
199255FNANA0NALBNDLaNAAlive
199259FNANA1bIV-MACND5TD
199461M2b00IIAPNPVP or VPVNBC1.5TR
1994NAM2b00NALBPVPNBC5TD
199427F1bNA0IALBEMA, PEAd36Alive
199569MNANA1bIV-UDNBC1.5TD
199654F3NA1bIVLBBOMP/EPIND12Alive
199629FNA0NA-BEP, CHAMOCA, MTXND72Alive
199669M2a00IBLBBEPNBC6Alive
199769M3NA1bIV-NDLa and UDC0ND
200060M200IB or IIA-UDNBC5TD
200061M200IB or IIALBNDGCC5TD
200161MNANANANAWRBEP, EMA/COAd6Alive
200158MNA20NALBNDLa5TD
200223MNANA1aIV-MACNBC0TD
200337FNANANANALBBEPNBC12Alive
200677M2b31bIV-NDAd and UDC0TD