Figure 1. Changes in WBC, AbMon, ANC and temperature max (Tmax) (°C) during 40 days of hospitalization. Shaded gray areas indicate time during which patient was admitted to ICU for different reasons. a: Start of voriconazole; b: Amiodarone started; c: Vancomycin stopped; d: Onset of severe neutropenia; e: Amiodarone discontinued. Absolute monocytes (AbMon) value was multiplied by 10 to achieve a comparable value. Normal reference value of AbMon: 0.2 to 1 × 109 cells/L; adjusted reference AbMon value: 2 to 10 × 109 cells/L. WBC: white blood cell; ANC: absolute neutrophil count; ICU: intensive care unit.