Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 11, Number 8, August 2020, pages 239-242

Transformation of Chronic Myeloid Leukemia to Acute Biphenotypic Leukemia


Figure 1.
Figure 1. Pathology immunohistochemical staining of bone marrow (a) and lymph node (b) demonstrating increased expression of PAX5 in the marrow sample significant for B-cell blast (CD34+) population versus no expression of PAX5 in lymph node sample despite presence of blast cells (CD34+) suggesting biphenotypic expression of the cell lines. Row a1: bone marrow, a2: bone marrow with CD34-positive expression, a3: bone marrow with significant expression of PAX5; Row b1: lymph node, b2: lymph node with positive CD34 expression, b3: lymph node without expression of PAX5.