Figure 1. Bone marrow sample (magnification, × 50). May-Grunwald-Giemsa staining of bone marrow aspirate shows two histiocytes with engulfed nucleated cells (one neutrophil (green arrow) and one erythroblast (red arrow)).
| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website http://www.journalmc.org |
Case Report
Volume 11, Number 7, July 2020, pages 211-214
Macrophage Activation in COVID-19 Patients in Intensive Care Unit
Figure
Table
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | |
|---|---|---|---|---|---|---|
| F: Female; M: male; NR: normal range; ASAT: aspartate amino transferase; MAS: macrophage activation syndrome; CRP: C-reactive protein; PCT: procalcitonin. | ||||||
| Gender | F | M | M | F | M | M |
| Age | 67 | 63 | 63 | 51 | 69 | 67 |
| Maximum temperature (°C) | 36.1 | 38.1 | 41 | 38.2 | 37.5 | 38.9 |
| Hepatomegaly, splenomegaly, lymphadenopathy | No | No | No | No | No | No |
| Leukocytes (109/L) (NR: 4.49 - 12.68) | 13.0 | 23.7 | 10.37 | 7.4 | 9.1 | 2.5 |
| Hemoglobin (g/dL) (NR: 11.9 - 14.6) | 11.1 | 8.5 | 13.5 | 8.3 | 10.0 | 7.8 |
| Platelets (109/L) (NR: 173 - 390) | 37 | 89 | 53 | 217 | 39 | 71 |
| Fibrinogen (g/L) (NR: 2.13 - 4.22) | 1.6 | 2.1 | 5.2 | 4.6 | 5.9 | 7.3 |
| Ferritin (ng/mL) (NR: 36 - 220) | 620 | 4,899 | 1,064 | 356 | 801 | 1,206 |
| Triglycerides (mmol/L) (NR: 0.5 - 1.7) | 1.15 | 5.62 | 2.65 | 7.24 | 1.37 | 1.62 |
| ASAT (UI/L) (NR < 37) | 43 | 84 | 107 | 22 | 71 | 24 |
| H-score | 84 | 207 | 147 | 148 | 35 | 102 |
| Probability of MAS% | 0.56 | 92.10 | 22.0 | 23.0 | 0.10 | 1.70 |
| Lymphocytes (109/L) (NR: 1.26 - 3.35) | 1.26 | 1.61 | 0.78 | 0.53 | 0.86 | 0.29 |
| CRP (mg/L) (NR: 0 - 3) | 208 | 278 | 75 | 223 | 129 | 213 |
| PCT (ng/mL) (NR < 0.5) | 20 | 105 | 125.3 | 108.2 | 0.9 | 3.1 |
| Death | Yes | Yes | Yes | No | Yes | No |