Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 11, Number 8, August 2020, pages 253-255

A Patient With Human Herpesvirus 8-Positive Multicentric Castleman’s Disease Who Met Criteria for TAFRO Syndrome: Controversy in Practice?


Figure 1.
Figure 1. (a) HHV-8-positive multicentric Castleman’s disease. Follicles with mantle zone B cells exhibiting target-like features surrounding follicular center with radially penetrating vasculature (hematoxylin and eosin stain, × 400). (b) HHV-8-positive/KSHV infected cells identified principally within the mantle cell zones (immunostaining for HHV-8 (latent nuclear antigen-1), × 200). HHV-8: human herpesvirus 8; KSHV: Kaposi’s sarcoma-associated herpesvirus.