| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
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Case Report
Volume 11, Number 12, December 2020, pages 375-378
Multisystemic Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection: A Case Series Report in a Pediatric Center in Mexico
Table
| Author | Toubiana et al, 2020 [9] | Whittaker et al, 2020 [10] | Feldstein et al, 2020 [11] | Davies et al, 2020 [12] | Belhadjer et al, 2020 [13] |
|---|---|---|---|---|---|
| SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; IVIG: intravenous immunoglobulin; KD: Kawasaki disease; KDSS: KD shock syndrome; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; AST: aspartate aminotransferase; ALT: alanine aminotransferase, LDH: lactate dehydrogenase; DD: D-dimer; NT-proBNP: N-terminal pro-brain-type natriuretic peptide; CAA: coronary artery abnormalities; NA: not available; IL: interleukin. | |||||
| County | France | UK | USA | UK | France/Switzerland |
| Patients | 21 | 58 | 186 | 78 | 35 |
| Median age (year) | 7.9 | 9 | 8.3 | 11 | 10 |
| Male (%) | 43 | 66 | 62 | 66 | 51 |
| KD complet/incomplete (%) | 55/NA | 22/NA | 20.4/19.3 | NA | - |
| KDSS (%) | 57% | - | - | NA | - |
| Epidemiological contact (%) | 48 | 29.5 | NA | 37 | |
| SARS-CoV-2 positive (%) | 90 | 78 | 70 | 64 | 88.5 |
| Gastrointestinal system (%) | 100 | 45-53 | 92 | 90 | 83 |
| Shock (%) | 57 | 50 | NA | 87 | 80 |
| Myocardial dysfunction (%) | 76 | 31 | 33 | NA | 72 |
| Neurological system (%) | 29 | 26 | 7 | 87 | NA |
| Laboratory findings | ↓ Lymphocytes, albumin and serum sodium; ↑ CRP, procalcitonin, ALT, DD, NT-proBNP and IL-6 | ↓ Lymphocytes, albumin serum; ↑ CRP, ferritin, neutrophils, troponin I and NT-proBNP | ↓ Lymphocytes, albumin serum and platelets; ↑ CRP, neutrophils, ferritin, DD, fibrinogen, troponin I and NT-proBNP, and ALT | ↓ Lymphocytes, platelets; ↑ CRP, ferritin, DD and troponin I | ↓ Lymphocytes; ↑ CRP, troponin I, ferritin, DD and IL-6 |
| CAA (%) | 24 | NA | NA | 36 | 17 |
| Coronary aneurisms (%) | 0 | 14.5 | 8 | 23 | 0 |
| IVIG (%) | 100 | 71 | 77 | 76 | 71 |
| Second dose IVIG (%) | 24 | NA | 21 | NA | 2.8 |
| Systemic steroids (%) | 48 | 64 | 49 | 73 | 34 |
| Fluid resuscitation (%) | 52 | 79 | NA | 92 | NA |
| Vasoactive and inotropic agents (%) | 71 | 47 | 48 | 83 | 80 |
| Mechanical ventilation (%) | 52 | 43 | 20 | 46 | 62 |
| Biologic therapy (%) | 0 | 19 | 21 | 22 | 8 |
| Anticoagulation therapy (%) | 0 | 0 | 47 | 50 | 65 |
| Death (%) | 0 | 2 | 2 | 2.5 | 0 |