| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website https://www.journalmc.org |
Case Report
Volume 12, Number 1, January 2021, pages 9-12
Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium)
Tables
| Test | First test | After 4 months | Normal range |
|---|---|---|---|
| Prothrombin time (s) | 27.3 | 14.4 | 11 - 16 |
| Partial thromboplastin time (s) | 42 | 29 | 18 - 28 |
| Hemoglobin (g/dL) | 10 | 12 | 12 - 15.5 |
| The Naranjo adverse drug reaction probability scale | Yes | No | Do not know | Scale |
|---|---|---|---|---|
| Are there previous conclusive reports on this reaction? | + 1 | 0 | 0 | 0 |
| Did the adverse event occur after the suspected drug was administered? | + 2 | - 1 | 0 | 2 |
| Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered? | + 1 | 0 | 0 | 1 |
| Did the adverse reaction reappear when the drug was readministered? | + 2 | - 1 | 0 | 0 |
| Are there alternative causes (other than the drug) that could have on their own caused the reaction? | - 1 | + 2 | 0 | 2 |
| Did the reaction reappear when a placebo was given? | - 1 | + 1 | 0 | 1 |
| Was the blood detected in the blood (or other fluids) in concentrations known to be toxic? | + 1 | 0 | 0 | 0 |
| Was the reaction more severe when the dose was increased or less severe when the dose was decreased? | + 1 | 0 | 0 | 1 |
| Did the patient have a similar reaction to the same or similar drugs in any previous exposure? | + 1 | 0 | 0 | 0 |
| Was the adverse event confirmed by any objective evidence? | + 1 | 0 | 0 | 1 |
| Total | 8 |