Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 12, Number 2, February 2021, pages 79-83

Hepatic Hodgkin Lymphoma Presenting as Solitary Hepatic Mass Following Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder in a Patient With Rheumatoid Arthritis

Figures

Figure 1.
Figure 1. Images of hepatic mass. (a) CT images showed a solitary low-density mass in the right lobe of the liver. MRI showed a low-intensity solitary hepatic mass on T1-weighted image (b), a high-intensity mass on T2-weighted image (c), and a high-intensity mass on diffusion-weighted image (d). (e) PET-CT images showed abnormal accumulation of fluorodeoxyglucose in liver (arrow); (upper panel) whole-body PET-CT image, (lower panel) transverse section of PET-CT image. (f) PET-CT images after four courses of BV combination chemotherapy showed no abnormal accumulation of fluorodeoxyglucose in whole body, which indicated that she remained in complete metabolic remission; (upper panel) whole-body PET-CT image, (lower panel) transverse section of PET-CT image. CT: computed tomography; MRI: magnetic resonance imaging; PET-CT: positron emission tomography computed tomography.
Figure 2.
Figure 2. Histopathological findings of biopsied liver sample. (a) Diffuse infiltration of many cells was observed on the right side of the biopsied liver sample. Normal hepatocytes were observed on the left side (hematoxylin and eosin staining; original magnification, × 10). (b) Immunohistochemical analysis showed that small inflammatory cells were positive for CD3 (original magnification, × 400). (c) Immunohistochemical analysis showed that abnormal cells were positive for CD30 (original magnification, × 400). (d) Epstein-Barr virus-encoded small RNAs (EBERs) in situ hybridization was positive for abnormal cells (original magnification, × 400). (e) The Ki-67 index was high (original magnification, × 400).