Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 12, Number 10, October 2021, pages 400-404

Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes Associated With Castleman Disease: A Common Misdiagnosis


Figure 1.
Figure 1. Histological findings in the surgical specimen. (a) A germinal center with lymphocyte depletion; small dark lymphocytes concentrically arranged in the mantle zone (hematoxylin and eosin (H&E), × 400). (b) Interfollicular regions expanded by sheets of plasma cells and vascular proliferation (H&E, × 100). (c) Immunohistochemical staining for human herpes virus-8 (HHV-8, × 400).
Figure 2.
Figure 2. Histological findings in the bone marrow biopsy specimen. (a) Elements from the three hematopoietic lineages with normal density, location and maturation (hematoxylin and eosin (H&E), × 100). (b, c) Positive immunohistochemical staining for plasma cells accounting for about 5% of the total cell population ((b) CD138, × 400); (c) MUM1, × 400). (d) Negative immunohistochemical staining for human herpes virus-8 (HHV-8, × 400).
Figure 3.
Figure 3. Bone windows of computed tomography scan showing: (a) diffuse sclerotic lesions and (b) sclerotic lesion in right ischium.