Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 13, Number 6, June 2022, pages 257-262

Esophageal Pancreatic Acinar Heterotopia: Premalignant or Benign

Figures

Figure 1.
Figure 1. Endoscopy image of raised mucosa at gastroesophageal junction.
Figure 2.
Figure 2. Irregular mucosa on endoscopic evaluation of gastroesophageal junction.
Figure 3.
Figure 3. Glandular mucosa of esophagus with arrow pointing to focal pancreatic acinar tissue (H&E, × 100 magnification).
Figure 4.
Figure 4. Glandular mucosa with arrow pointing to intestinal metaplasia (H&E, × 100 magnification).

Tables

Table 1. Brief Literature Review of EPAH Case Series
 
LiteratureAge rangeNumber of casesLocationAssociated findings
EPAH: esophageal pancreatic acinar heterotopia; GEJ: gastroesophageal junction.
Wang et al [9]18 - 8937GEJOxyntic mucosa, oxyntocardiac mucosa, intestinal metaplasia
Schneider et al [15]< 20 to > 70184GEJNone

 

Table 2. Brief Literature Review of EPAH Reports
 
AgeSexLocationSymptomsTreatmentAssociated findingsOutcome
EPAH: esophageal pancreatic acinar heterotopia; GEJ: gastroesophageal junction; DE: distal esophagus; ME: middle esophagus; PE: proximal esophagus; RUQ: right upper quadrant.
Crighton et al [11]58FGEJDysphagiaEsophagectomyIntraductal papillary mucinous neoplasmResolution
Mack et al [12]25MDERUQ and Epigastric painResectionNoneResolution
Ulrych et al [13]34MDESevere dysphagia, odynophagia, weight lossEsophagectomyInflammationResolution
Noffsinger et al [20]47FDEEpigastric painIvor-Lewis esophagogastrectomy, pyloroplasty, and a Witzel jejunostomy.Inflammation, fat necrosis and fibrosisRehabilitation
Salo et al [21]60MMEEpigastric painMinimal McKeown esophagectomyModerately differentiated adenocarcinomaRecurrence
Guillou et al [22]60MGEJEpigastric painResectionDuctal adenocarcinomaPostoperative complication - pneumonia
Roshe at al [23]45MDEDysphagiaEsophagogastrectomyAnaplastic carcinomaResolution
Razi [24]43MDEHemoptysisResectionNoneResolution
Yamagiwa et al [25]< 1MPENoneNoneCongenital, esophageal atresia with tracheoesophageal fistulaNone
Gananadha et al [26]26FDEEpigastric painResectionPancreatitis, Active chronic inflammation with cystic dilated ducts, metaplasiaResolution
Lowry et al [27]25MGEJEpigastric painResectionNoneResolution