Figure 1. Nerve conduction study. F: frequency; ms: millisecond; mV: millivolt; NCS: nerve conduction study; R: right; Rep: repetitive; Stim: stimulation.
| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website https://www.journalmc.org |
Case Report
Volume 13, Number 11, November 2022, pages 530-535
Pembrolizumab-Induced Myasthenia Gravis and Myositis: Literature Review on Neurological Toxicities of Programmed Death Protein 1 Inhibitors
Figure
Table
| Laboratory test | Day 1 | Day 4 | Day 9 | Day 16 |
|---|---|---|---|---|
| Ab: antibody; Ach: acetylcholine; AchR: acetylcholine receptor; AMA: antimitochondrial antibody; ANA: antinuclear antibody; CK: creatine kinase; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; FT4: free thyroxine; IgG: immunoglobulin G; LRP4: low-density lipoprotein receptor-related protein 4; MuSK: muscle-specific kinase; PM: polymyositis; Pro- BNP: brain natriuretic peptide; RNP: ribonucleoprotein; SMA: smooth muscle antibody; SRP: signal recognition particle; SSA: Sjogren syndrome-related antigen A; TSH: thyroid-stimulating hormone; VGCC: voltage-gated calcium channel. | ||||
| CK, U/L | 6,500 | 9,244 | 5,841 | 1,115 |
| Troponin, ng/mL | 1.43 | 1.72 | 4.4 | 3.56 |
| CK-MB, ng/mL | 153 | 207 | 31.3 | 29.8 |
| Pro-BNP, pg/mL | 8,205 | |||
| TSH, µIU/mL | 28.25 | |||
| FT4, ng/dL | 0.6 | |||
| ESR, mm/h | 89 | |||
| CRP, mg/L | 117 | |||
| VGCC Ab, pmol/L | 0.0 | |||
| Anti-Jo-1 Ab, U | < 20 | |||
| Anti-U3 RNP | Negative | |||
| Anti-U2 snRNP | Negative | |||
| Anti-U1 RNP, U | < 20 | |||
| PL-7 PL-12 | Negative | |||
| EJ OJ | Negative | |||
| SRP | Negative | |||
| MI-2 | Negative | |||
| TIF-gamma P155/140 | Negative | |||
| MDA-5 (P140), U | < 20 | |||
| NXP-2, U | < 20 | |||
| Anti-PM/Scl-100, U | < 20 | |||
| Ku | Negative | |||
| Anti-SSA IgG, U | < 20 | |||
| AchR Ab | 14% | |||
| Ach modulating Ab | 0% | |||
| P/Q type Ab, nmol/L | 0.01 | |||
| LRP4 Ab | Negative | |||
| MuSK Ab, U/mL | < 1 | |||
| AMA | < 1:20 | |||
| Microsomal antibody assay | < 20.1 | |||
| SMA | < 1:20 | |||
| ANA | Negative | |||