J Med Cases

Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc

Journal website https://www.journalmc.org

Case Report

Volume 15, Number 2-3, April 2024, pages 60-65

Upper Tract Urothelial Carcinoma Complicated by Skeletal Muscle Metastases

Figure 1. Widespread intramuscular metastases, axial views, seen in areas of increased uptake depicted with warmer colors. (a) Left gluteal muscle. (b) Right deltoid muscle. (c) Right vastus lateralis muscle. (d) Left calf musculature.

Figure 2. Widespread intramuscular metastases, coronal views, seen in areas of increased uptake depicted with warmer colors. (a) Left sternocleidomastoid, right deltoid, right vastus lateralis, and left thigh intramuscular metastases visible. (b) Left gluteal and left calf intramuscular metastases visible.

**Table 1.** Review of the Literature of Urothelial Cell Carcinoma With Skeletal Muscle Metastasis
Citation	Sex	Age (years)	UCC stage	Skeletal muscle metastasis location	Treatment(s)	Outcome
UCC: urothelial cell carcinoma.
Dang et al, 2022 [14]	Male	72	Unknown	Posterior muscles of left thigh	Unknown	Unknown
Dell’Atti, 2015 [8]	Male	65	pT2a	Left obturator	Chemotherapy, local radiation	Alive at 6 months
Doo et al, 2012 [9]	Male	45	T2	Left sartorius	Chemotherapy, local radiation	Unknown
Ekici et al, 1999 [15]	Male	41	Unknown	Right deltoid	Unknown	Unknown
Guidi et al, 2016 [11]	Male	76	T3	Right flexor digitorum superficialis and profundus	Resection, local radiation, chemotherapy	Died within 5 months
Kashyap et al, 2010 [16]	Male	64	Unknown	Right adductor brevis, quadriceps femoris, gastrocnemius; left quadriceps and semitendinosus	Unknown	Unknown
Katafigiotis et al, 2014 [17]	Male	51	pT2	Left sartorius	Resection, local radiation, chemotherapy	Alive at 5 months
Koca et al, 2014 [4]	Male	62	T1G3	Right iliopsoas and right adductor longus	Chemotherapy	Died within 3 months
Mainwaring et al, 2019 [3]	Male	71	pT3aN0	Right vastus lateralis	Immunotherapy, local radiation, chemotherapy	Alive as of case report writing
Nabi et al, 2003 [13]	Male	65	T3	Medial thigh muscles	Chemotherapy	Died within 8 months
Nabi et al, 2003 [13]	Male	27	T3bN2	Left psoas	Chemotherapy, local radiation	Died within 6 months
Nabi et al, 2003 [13]	Male	62	T3a	Left rectus abdominis	Chemotherapy	Died within 12 months
Nabi et al, 2003 [13]	Male	70	T3bN2	Left psoas	Chemotherapy, local radiation	Died within 8 months
Nabi et al, 2003 [13]	Male	36	T3aN1	Left psoas	Chemotherapy	Died within 6 months
Nagao et al, 2004 [18]	Male	63	Unknown	Right gluteus maximus	Unknown	Unknown
Rossly et al, 2021 [7]	Male	55	pT2	Left gastrocnemius	Local radiation	Alive as of case report writing
Spinelli et al, 2018 [19]	Male	66	Unknown	Left gluteus	None	Died within 1 month
Ying-Yue et al, 2010 [20]	Male	83	Unknown	Bilateral psoas major, quadratus lumborum, iliacus, gluteus medius/minimus, obturator externus, quadratus femoris, adductor brevis/magnus	Chemotherapy	Unknown

Table 1. Review of the Literature of Urothelial Cell Carcinoma With Skeletal Muscle Metastasis

Citation

Sex

Age (years)

UCC stage

Skeletal muscle metastasis location

Treatment(s)

Outcome

UCC: urothelial cell carcinoma.

Dang et al, 2022 [14]

Male

Unknown

Posterior muscles of left thigh

Unknown

Dell’Atti, 2015 [8]

Male

pT2a

Left obturator

Chemotherapy, local radiation

Alive at 6 months

Doo et al, 2012 [9]

Male

Left sartorius

Chemotherapy, local radiation

Unknown

Ekici et al, 1999 [15]

Male

Unknown

Right deltoid

Unknown

Guidi et al, 2016 [11]

Male

Right flexor digitorum superficialis and profundus

Resection, local radiation, chemotherapy

Died within 5 months

Kashyap et al, 2010 [16]

Male

Unknown

Right adductor brevis, quadriceps femoris, gastrocnemius; left quadriceps and semitendinosus

Unknown

Katafigiotis et al, 2014 [17]

Male

pT2

Left sartorius

Resection, local radiation, chemotherapy

Alive at 5 months

Koca et al, 2014 [4]

Male

T1G3

Right iliopsoas and right adductor longus

Chemotherapy

Died within 3 months

Mainwaring et al, 2019 [3]

Male

pT3aN0

Right vastus lateralis

Immunotherapy, local radiation, chemotherapy

Alive as of case report writing

Nabi et al, 2003 [13]

Male

Medial thigh muscles

Chemotherapy

Died within 8 months

Nabi et al, 2003 [13]

Male

T3bN2

Left psoas

Chemotherapy, local radiation

Died within 6 months

Nabi et al, 2003 [13]

Male

T3a

Left rectus abdominis

Chemotherapy

Died within 12 months

Nabi et al, 2003 [13]

Male

T3bN2

Left psoas

Chemotherapy, local radiation

Died within 8 months

Nabi et al, 2003 [13]

Male

T3aN1

Left psoas

Chemotherapy

Died within 6 months

Nagao et al, 2004 [18]

Male

Unknown

Right gluteus maximus

Unknown

Rossly et al, 2021 [7]

Male

pT2

Left gastrocnemius

Local radiation

Alive as of case report writing

Spinelli et al, 2018 [19]

Male

Unknown

Left gluteus

None

Died within 1 month

Ying-Yue et al, 2010 [20]

Male

Unknown

Bilateral psoas major, quadratus lumborum, iliacus, gluteus medius/minimus, obturator externus, quadratus femoris, adductor brevis/magnus

Chemotherapy

Unknown