Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
Journal website https://www.journalmc.org

Case Report

Volume 15, Number 4-5, May 2024, pages 82-91

Improvements in Gut Microbiome Composition and Clinical Symptoms Following Familial Fecal Microbiota Transplantation in a Nineteen-Year-Old Adolescent With Severe Autism

Figures

Figure 1.
Figure 1. Gut microbiome profile in species level for the patient and donor (a). Species Lactobacillus animalis relative abundance in donor and subject (b). FMT: fecal microbiota transplant.
Figure 2.
Figure 2. Gut microbiome profile in phylum level for the patient and donor (a). Relative abundance in phylum Proteobacteria (b). Relative abundance in phylum Actinobacteria (c). FMT: fecal microbiota transplant.
Figure 3.
Figure 3. Gut microbiome profile in genus level for the subject and donor. FMT: fecal microbiota transplant.
Figure 4.
Figure 4. Improvements of CARS scores post FMT. CARS: Childhood Autism Rating Scale; FMT: fecal microbiota transplant.
Figure 5.
Figure 5. Improvements of ATEC scores post FMT. ATEC: Autism Treatment Evaluation Checklist; FMT: fecal microbiota transplant.

Table

Table 1. Shannon Index of Bacterial Diversity
 
TimepointShannon index (patient)Shannon index (donor)
FMT: fecal microbiota transplant.
Baseline2.26.7
Month 2 post-FMT5.1-
Month 6 post-FMT6.0-
Month 8 post-FMT6.2-
Month 11 post-FMT5.9-
Month 15 post-FMT6.5-