Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
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Case Report

Volume 15, Number 10, October 2024, pages 278-282

Catastrophic Antiphospholipid Syndrome in a Lupus Patient With Severe Recurrent Life-Threatening Clinical Manifestations

Figures

Figure 1.
Figure 1. Computed tomography image of abdomen upon diagnosis. Arrows show multiple focal hypoattenuation lesions mainly at right hepatic lobe and irregular margins with marginal enhancement lesion and multiple hepatic infarcts.
Figure 2.
Figure 2. Kidney biopsy results showing extensive thrombotic microangiopathy consistent with antiphospholipid syndrome. Extensive glomerular and focal arterial recent thrombotic microangiopathy is seen with ischemic changes of perfused glomeruli. Immunofluorescence microscopy and electron microscopy have not shown any evidence of immune complex deposits therefore a concomitant lupus nephritis is unlikely. Electron microscopy shows re-modeling of glomerular basement membrane consistent and significant podocytopathy. Mild chronic parenchymatous damage is seen (arrows).