J Med Cases

Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc

Journal website https://www.journalmc.org

Case Report

Volume 15, Number 11, November 2024, pages 324-329

Tonsillar Diffuse Large B-Cell Lymphoma of Non-Germinal Center Type With Cluster of Differentiation 5 Positive in a Pediatric Girl

Figure 1. (a) Small axillary lymph nodes (arrow). (b) No mediastinal or hilar lymph nodes (arrow). (c) Small cervical lymph nodes (arrow).

Figure 2. (a) Hematoxylin and eosin staining, × 100. The straight horizontal line and black arrows point at the infiltrates that are composed of large cells with high nucleo-cytoplasmic ratio, vesicular nuclei, and inconspicuous nucleoli. (b) A malignant lymphocyte with positive CD20 and positive CD5 (Ki-67 proliferation index of about 80%) (black arrow). (c) Malignant B cells that are positive for CD20 (black arrow). (d) Malignant B cells that are positive for CD5 (black arrow). (e) Malignant B cells that are positive for Ki-67 (black arrow). Ki-67: antigen Kiel 67; CD: cluster of differentiation.

**Table 1.** Review of the Tonsillar Lymphoma Literature
Study	Year	Study design	Age/sex	Presenting signs	Diagnosis
DLBCL: diffuse large B-cell lymphoma; M: male; F: female.
[12]	2022	Case report	13/M	Left-sided headache, diplopia and left parapharyngeal mass	DLBCL
[13]	2021	Case report	10/M	Dysphagia, pharyngodynia, hypersalivation orthopnea and asymmetrical tonsils	DLBCL
[6]	2021	Case report	59/M	Sore throat, dysphagia, odynophagia, snoring and tonsillar swelling	DLBCL
[2]	2021	Case report	65/M	Tonsillar swelling, dysphagia, and dysphonia	DLBCL
[19]	2021	Case report	40/M	Tonsillar swelling, dysphagia, suffocation, and snoring	DLBCL
[20]	2020	Case report	50/M	Odynophagia, painful cervical swelling, and tonsillar enlargement	DLBCL
[14]	2016	Case report	5/M	Snoring, nasal obstruction, hyponasal speech, obstructive sleep apnea, abnormal sleep position, adenoidal hypertrophy and left tonsillar enlargement	Burkitt’s lymphoma
[15]	2012	Case report	6/M	Night stridor, and enlarged left tonsil	Tonsillar follicular lymphoma
[16]	2012	Case report	4/M	Sore throat, otalgia, snoring, difficulty breathing and right tonsillar mass	Burkitt’s lymphoma
[17]	2002	Case report	Case1: 7/F	Case1: left-sided pharyngeal mass, snoring and change of voice	Burkitt’s lymphoma
			Case2: 10/M	Case2: recurrent sore throat, change of voice and right palatine tonsil mass

Table 1. Review of the Tonsillar Lymphoma Literature

Study

Year

Study design

Age/sex

Presenting signs

Diagnosis

DLBCL: diffuse large B-cell lymphoma; M: male; F: female.

[12]

2022

Case report

13/M

Left-sided headache, diplopia and left parapharyngeal mass

DLBCL

[13]

2021

Case report

10/M

Dysphagia, pharyngodynia, hypersalivation orthopnea and asymmetrical tonsils

DLBCL

[6]

2021

Case report

59/M

Sore throat, dysphagia, odynophagia, snoring and tonsillar swelling

DLBCL

[2]

2021

Case report

65/M

Tonsillar swelling, dysphagia, and dysphonia

DLBCL

[19]

2021

Case report

40/M

Tonsillar swelling, dysphagia, suffocation, and snoring

DLBCL

[20]

2020

Case report

50/M

Odynophagia, painful cervical swelling, and tonsillar enlargement

DLBCL

[14]

2016

Case report

5/M

Snoring, nasal obstruction, hyponasal speech, obstructive sleep apnea, abnormal sleep position, adenoidal hypertrophy and left tonsillar enlargement

Burkitt’s lymphoma

[15]

2012

Case report

6/M

Night stridor, and enlarged left tonsil

Tonsillar follicular lymphoma

[16]

2012

Case report

4/M

Sore throat, otalgia, snoring, difficulty breathing and right tonsillar mass

Burkitt’s lymphoma

[17]

2002

Case report

Case1: 7/F

Case1: left-sided pharyngeal mass, snoring and change of voice

Burkitt’s lymphoma

Case2: 10/M

Case2: recurrent sore throat, change of voice and right palatine tonsil mass