| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website http://www.journalmc.org |
Case Report
Volume 3, Number 4, August 2012, pages 226-228
Probable Bexarotene Hepatotoxicity Associated With Transient Serum Antimitochondrial Antibodies
Table
| Type of liver injury | Hepatocellular (first exposure) | Points |
|---|---|---|
| Time of onset of the event | First exposure | - |
| Time from drug intake until reaction onset | < 5 or > 90 days | + 1 |
| Course of the reaction | > 50% improvement 30 days | + 2 |
| Risk factors | ||
| Alcohol | No | + 0 |
| Age ≥ 55 years | No | + 0 |
| Concomitant therapy | Time to onset incompatible | + 0 |
| Exclusion of nondrug-related causes | Ruled out | + 2 |
| Previous information on hepatotoxicity | Reaction labeled in product's characteristics | + 2 |
| Response to re-administration | Not available | + 0 |
| Total score | Probable | + 7 |