Rosai-Dorfman Disease Confined to the Breast

Thais Helena de Souza Silotti, Maria Riselda Vinhote da Silva, Nilton Cesar O Bessa, Ione Rodrigues Brun, Livia Moura de Oliveira


The Rosai-Dorfman (also known as sinus histiocytosis with massive lymphadenopathy), was described in 1969 by Rosai and Dorfman, and is considered a rare disease of unknown aetiology characterized by benign histiocytic lymphadenopathy in the neck and extranodal sites. The involvement of the breast is rare and often simulates invasive breast carcinoma in its clinical presentation and radiological findings. There are currently about 20 cases reported in the literature, and recognition of this uncommon condition, when it occurs in an atypical location such as breast, is extremely difficult. The research aims to report a case of Rosai-Dorfman breast in a woman aged 37, with ill-defined mass in the left breast. Highlighting the immunohistochemical study of biopsy material, and it diffused expression for S-100 protein in histiocytic cells of the parenchyma.

J Med Cases. 2013;4(8):519-522


Rosai-Dorfman; Sinus histiocytosis; Breast

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