Sporadic Pediatric GIST With Novel Gene Mutation

Shagufta Jabeen, Jagannathan Krishnasamy, Sohail Iqbal, Andrew Fagbemi, Ross J Craigie

Abstract


Advanced understanding of pathogenesis and tumor metabolism has increased the number of recently diagnosed gastrointestinal stromal tumors. We present a case of a young girl who attended our hospital with an episode of melena. Endoscopy revealed an irregular gastric lump with overlying ulceration. Following further investigation and biopsy, a gastrointestinal stromal tumor of the stomach was diagnosed and subsequently resected. Histopathology showed mixed type of epithelioid and spindle cells with exon 11 KIT mutations. Early diagnosis, prompt management, and long-term follow-up are the key prognostic determinants.




J Med Cases. 2013;4(11):722-725
doi: https://doi.org/10.4021/jmc1491w

Keywords


Gastrointestinal stromal tumor; GIST; KIT mutation; Irregular gastric lump; Melena

Full Text: HTML PDF
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org    elmer.editorial@hotmail.com
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.


Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.