Acute Delirium Induced by Carvedilol: A Case Report

Kraig K. Wasik, Andrew D. Michaels


Acute delirium has been reported associated with beta-blocker treatment, including propranolol, atenolol, and metoprolol. We report the first reported case of acute onset of acute delirium in a patient treated with carvedilol with complete reversal after treatment withdrawal. The patient was hospitalized for an acute coronary syndrome with left ventricular systolic dysfunction, treated with percutaneous coronary intervention. He developed acute delirium shortly after starting carvedilol on his third hospital day. Other causes of delirium were excluded, and the delirium resolved within 24 hours of carvedilol discontinuation. Carvedilol is an alpha1- and beta-adrenergic antagonist with moderate lipid solubility that is eliminated by hepatic metabolism. Given the moderate lipophilicity, carvedilol could certainly penetrate the central nervous system. Our case suggests that carvedilol should be considered among the medications that may cause acute organic brain syndrome.

J Med Cases. 2013;4(11):732-733


Delirium; Carvedilol; Beta-blocker

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.