Pigmented Villonodular Synovitis for Combined Therapy

Alexander P Rozin, Gabriel Nierenberg, Euvgeni Vlodavsky, Kohava Toledano, Natanel Meushar, Kamal Yassin, Rahamim Ben-Yosef


Pigmented villonodular synovitis (PVNS), inflammatory proliferative disease resulting from synovial cells, has progressive course similar neoplastic local expansion. We followed up a case with effective combined therapy for diffuse PVNS despite incomplete response to its components and reviewed therapies based on MedLine for PVNS. Due to US data residue synovitis after open radical synovectomy, we made decision about external beam radiotherapy. Photon radiation with linear accelerator energy of 6 MV was applied for two fields: anterior and posterior. The total dose was 20 Gy, delivered in 2 Gy a day, five times a week. Due to postoperative pain and the rest of synovial tissue on US study, pharmacologic therapy with salazopyrine and celecoxib was added. For several weeks, the knee pain became episodic and further disappeared. Six months later, the patient feels healthy and continues to take salazopyrine permanently and celecoxib as needed. We conclude high rate response analyzing literature data and our case to combined therapy: arthroscopic or open surgery followed by RT along with complimentary pharmacotherapy.

J Med Cases. 2014;5(3):147-151
doi: http://dx.doi.org/10.14740/jmc1656e


Pigmented villonodular synovitis; Open synovectomy; External beam radiotherapy; Anti-inflammatory medications

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