Cold Urticaria: A Rare Manifestation of Lymphoma

Sadan Soyyigit, Zeynep Celebi Sozener, Erden Atilla, Aylin Okcu Heper, Gulsah Kaygusuz, Betul Ayse Sin


Cold urticaria (CU) is characterized by the rapid onset of pruritus, erythema, and swelling after exposure to cold stimulus. CU can be classified into acquired and familial disorders. Acquired cold urticaria (ACU) is sometimes associated with serious underlying diseases, such as malignancies, systemic leukocytoclastic vasculitis and infectious diseases. A 55-year-old man was admitted to our hospital with 1-year history of urticarial rash, itching and angioedema on the parts of his body after cold exposure. He had no family history. Diagnosis was confirmed by applying ice cube test. Marginal zone B-cell lymphoma has not yet been reported as a cause of secondary ACU. Here, we report a patient with secondary ACU which was also diagnosed as marginal zone B-cell lymphoma.

J Med Cases. 2015;6(1):40-42


Cold urticaria; Lymphoma; Marginal zone B-cell lymphoma; Acquired secondary cold urticaria; Leukocytoclastic vasculitis; Cryoglobulinemia

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.