Silicone Breast Implants as Predisposing Factor for Non-Hodgkins Lymphoma: An Additional Facet of Auto-Inflammatory Syndrome Induced by Adjuvant

Idan Goren, Dana Doron, Orith Portnoy, Yehuda Shoenfeld, Gad Segal


Autoimmune disorders are already established as risk factors for later development of lymphoproliferative disease, i.e. non-Hodgkins lymphoma (NHL). The recently defined autoimmunity syndrome induced by adjuvants (ASIA syndrome) involves autoimmunity ignited by the mere presence of various adjuvants (e.g. components of certain vaccines) triggering autoimmunity. A causative relation between ASIA-related autoimmunity and later development of NHL has not yet been shown. The current case presents a 77-year-old patient, diagnosed to have NHL 13 years following cosmetic bilateral breast augmentation (with silicone implants) surgery. The authors regard the silicone implants of this patient as the trigger for ASIA syndrome later causing her subsequent lymphoproliferative disease.

J Med Cases. 2014;5(7):413-416


Lymphoma; Silicone implants; Auto-inflammatory syndrome induced by adjuvant; Autoimmunity; Autoimmune hemolytic anemia

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