A Case of Crizotinib-Resistant Lung Adenocarcinoma Harboring a KRAS Mutation and an EML4-ALK Fusion Gene

Satoshi Anai, Kunihiro Suzuki, Kayo Ijichi, Taishi Harada, Gouji Toyokawa, Takashi Seto, Mitsuhiro Takenoyama, Koichi Takayama, Yukito Ichinose, Yoichi Nakanishi

Abstract


Here, we report a case of lung adenocarcinoma resistant to crizotinib harboring KRAS mutation and the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene. Our case suggests that KRAS mutation in addition to EML4-ALK fusion gene may cause the resistance to crizotinib.




J Med Cases. 2014;5(12):631-633
doi: http://dx.doi.org/10.14740/jmc1985w

Keywords


EML4-ALK fusion gene; KRAS gene mutation; Crizotinib

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