A Rare Case of Cutaneous Gamma Delta T-Cell Lymphoma With Complete Body Involvement

Rahul Anil, Sana Grover, Adarsh Hiremath


A 57-year-old female presented to the emergency department of our hospital with painful skin lesions since 3 months. On examination, ulcerating tumors and plaques occupied 100% of her body and enlarged firm left axillary lymph nodes were present. On imaging, PET scan revealed hypermetabolic cutaneous lesion, and hyperactive B/L axillary, inguinal and intra-parotid lymph nodes. Punch biopsy from right medial thigh skin lesion showed phenomenon of epidermotropism. PCR studies showed strong expression of TCR gamma by atypical cells. FNAC of axillary lymph node and bone marrow biopsy was negative. Based on histo-immunological evidence and dermatologist input, the diagnosis of cytotoxic cutaneous gamma delta T-cell lymphoma (CGDTCL) was made. Patient received five cycles of total skin electron beam therapy. Contrary to the present literature that suggests that cutaneous gamma delta T-cell lymphomas are resistant to chemotherapy and radiation, our patient responded very well to total skin electron beam radiation therapy. The tumors on her body flattened with complete resolution of pain and pruritis. This case report summarizes the unusual presentation of CGDTCL and response to treatment.

J Med Cases. 2016;7(8):364-367
doi: http://dx.doi.org/10.14740/jmc2584w


Cutaneous T-cell lymphoma; Mycosis fungoides; T-cell receptor gamma

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.