Eosinophilia With Hepatic Mass and Abnormal Liver Function Tests: An Unusual Presentation of Chronic Myeloid Leukemia

Neeraja Yerrapotu, Susmitha Edappallath, Mohammad Jarrar, Caroline Hamm, Pat Allevato, Ali Gabali, Indryas Woldie


Chronic myeloid leukemia (CML) is a chronic myeloproliferative neoplasm characterized by excess granulocytes at different stages of maturation and the presence of BCR-ABL1 fusion gene or Philadelphia chromosome. Absolute eosinophilia, basophilia, and monocytosis are not uncommon in CML. However, a rare entity called eosinophilic variant of CML (eoCML) can present with eosinophilia without excess neutrophils or basophils. Here, we report a rare and unusual case of eoCML presenting as a liver mass with abnormal liver function tests, which has not been reported in the literature so far.

J Med Cases. 2020;11(7):196-200
doi: https://doi.org/10.14740/jmc3513


Chronic myeloid leukemia; BCR-ABL; Hypereosinophilic syndrome; Chronic myelomonocytic leukemia

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