Macrophage Activation in COVID-19 Patients in Intensive Care Unit

Guylaine Labro, Louise Marie Jandeaux, Andreea Rusu, Edouard Virot, Valentin Pointurier, Luis Pinto, Cyrille Mathien, Agathe Debliquis, Ines Harzallah, Joy Mootien, Bernard Drenou, Khaldoun Kuteifan


We report six cases of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, admitted to intensive care unit (ICU), for whom bone marrow aspirate revealed hemophagocytosis. We compared their clinical presentation and laboratory findings to those that can be encountered during a hemophagocytic lymphohistiocytosis. These observations might evoke a macrophage activation mechanism different from the one encountered in the hemophagocytic lymphohistiocytosis (HLH).

J Med Cases. 2020;11(7):211-214


Macrophage activation; Hemophagocytic lymphohistiocytosis; COVID-19

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