Primary Thyroid Lymphoma as A Manifestation of Rapidly Growing Thyroid Causing Progressive Respiratory Distress

Chisho Hoshino, Akane Yamabe, Yoshiyuki Sekikawa, Kana Ishihara, Hiroshi Ikeda, Masashi Narita, Minoru Inoue


The author present a 73-year-old man with rapidly glowing neck mass. He had a 6-year history of hypothyroidism-associated with Hashimoto thyroiditis and maintained L-thyroxine replacement. He had noticed progressive dyspnea with rapid enlargement of the thyroid grand over a month. An incisional biopsy of the thyroid grand for combined pathology and immunohistochemistry revealed diffuse large B cell non-Hodgkins lymphoma with germinal center B-cell subtype. Primary thyroid lymphoma requires prompt diagnosis because of its ability to cause progressive compression symptoms. An incisional biopsy of the thyroid grand is required for combined pathology and immunohistochemistry. Combination chemotherapy can dramatically shrink the tumor and briefly resolve the compression symptoms.

J Med Cases. 2012;3(1):15-19


Primary thyroid lymphoma; Hashimoto thyroiditis; A diffuse large B cell non-Hodgkin

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