Carfilzomib-Induced Thrombotic Microangiopathy: Focus on Pathogenesis

Odianosen Eigbire-Molen, Daniela Hermelin, Douglas Blackall


Drug-induced thrombotic microangiopathies present in similar fashion but have varied pathogenic mechanisms. Carfilzomib is an irreversible proteasome inhibitor. Since its initial approval as a single agent for the treatment of relapsed or refractory multiple myeloma in 2012, there have been increasing reports of carfilzomib-induced thrombotic microangiopathy. However, the mechanism of this disease process is not fully understood. Without treatment, there is a high likelihood of end-organ damage, especially in the kidneys, and death. In recent reports, the lifesaving role of eculizumab, a terminal complement inhibitor, in managing and further preventing end-stage renal disease has been described. In this article, we present a case of carfilzomib-induced thrombotic microangiopathy in a patient with multiple myeloma and discuss the pathogenesis of thrombotic microangiopathy in this setting.

J Med Cases. 2022;13(6):274-280


Carfilzomib; Thrombotic microangiopathy; Therapeutic plasma exchange; Eculizumab; Atypical hemolytic uremia syndrome

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