Unique Variant of Zieve Syndrome With a Normal Reticulocyte Count

Apurva Vedire, Steven Imburgio, Harshavardhan Sanekommu, Rushi Patel, Haley Johnson, Sobaan Taj, Mohammad Hossain


Zieve syndrome is a rare diagnosis seen in patients with chronic alcohol use which consists of a distinct clinical triad of hyperlipidemia, hemolytic anemia, and jaundice. Patients typically have an elevated reticulocyte count due to the hemolytic nature of the anemia. We present the case of a 44-year-old female who was discovered to have an unusual variant of Zieve syndrome with a normal reticulocyte count, which was believed to be due to suppression of bone marrow from excessive alcohol consumption. She was treated with steroids and complete alcohol cessation, with remarkable improvement on subsequent follow-up. An exhaustive literature review of 31 documented cases of Zieve syndrome was conducted to better understand the clinical presentation and overall prognosis of these patients. This case report and literature review aimed to improve patient outcomes through increased recognition of this underrecognized syndrome.

J Med Cases. 2023;14(6):185-190
doi: https://doi.org/10.14740/jmc4077


Zieve syndrome; Hyperlipidemia; Hemolytic anemia; Jaundice

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