Cortical Blindness as an Unusual Adverse Drug Reaction

Caroline Wilson, Darren Leaning, Kate Shankland, Tobias Langheinrich, Ruth Batty, Penella J. Woll


Cortical blindness is a frightening and unusual adverse drug reaction that can be difficult to diagnose. It is characteristic of reversible posterior leukoencephalopathy syndrome (RPLS), which has been described as an idiosyncratic reaction to a variety of anti-cancer drugs. Here we describe a case of RPLS in a patient receiving treatment with an immunoconjugate, and review its association with anti-cancer drugs.

J Med Cases. 2010;1(2):47-50


Adverse drug reaction; Anton syndrome; IMGN901; Immunoconjugate; Leukoencephalopathy; Merkel cell cancer

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