Isolated Antiphospholipid Syndrome of the Central Nervous System With Positive Lupus Anticoagulant: Two Case Reports

Kazuya Takahashi


I present two cases of isolated antiphospholipid syndrome (APS) of the central nervous system (CNS) with positive lupus anticoagulant (LA). Both these cases were of the remitting-relapsing type, and optic neuritis and transverse myelitis were not observed. Anticardiolipin antibodies (aCL), anti-beta2 glycoprotein-I antibodies, and anti-aquaporin-4 antibodies were not detected. Previous reports suggested that both multiple sclerosis (MS) patients with a positive aCL titer and APS patients with an MS-like disease frequently exhibit a neuromyelitis optica-like clinical course and they were positive for aCL but not LA. These results indicate that LA-positive APS and aCL-positive APS cases might differ in terms of CNS involvement.




J Med Cases. 2010;1(3):108-110



Antiphospholipid syndrome; Multiple sclerosis; Lupus anticoagulant; Kaolin clotting time; Anticardiolipin antibodies

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