Toxic Megacolon due to Fulminant Amebic Colitis in a non Endemic Area

Sarah Hugelshofer, David Petermann, Christina Orasch, Lucas Liaudet


We report a case of fulminant necrotizing colitis and toxic megacolon in a middle-aged woman, due to infection with <i>Entamoeba histolytica</i> acquired in a non endemic zone of amebiasis, and requiring emergent total colectomy due to the occurrence of colon perforation and peritonitis. Fulminant colitis is a rare complication of amebiasis, which has been only exceptionally reported in the absence of a recent travel in endemic areas. In the case presented herein, we discuss the possible role of the use of large doses of loperamide, as well as that of a co-infection with Norovirus, in triggering the fulminant course of the disease.

J Med Cases. 2013;4(2):63-65


Amebic colitis; Toxic megacolon; Entamoeba histolytica; Norovirus; Loperamide

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