Isolated Russell Body Duodenitis with Concurrent Helicobacter Pylori Gastritis

Abstract

Russell body duodenitis (RBD) is a rare entity characterized by the accumulation of numerous cells with Russell bodies (RB) in the duodenal mucosa. The two previously reported cases were not associated with <i>H. pylori</i> infection. Herein, we report a case of RBD in a 59-year-old female patient with concurrent <i>H. pylori</i> gastritis. The polytypic nature of RB-containing plasma cells and the lack of immunoreactivity for cytokeratin indicate a benign nature. Our findings also support the notion that defective excretion of immunoglobulin, rather than the accumulation of <i>H. pylori</i>, is the underlying mechanism for RB formation.




J Med Cases. 2013;4(3):166-169
doi: https://doi.org/10.4021/jmc905w