J Med Cases
Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
Journal website http://www.journalmc.org

Case Report

Volume 4, Number 3, March 2013, pages 153-155

A Complication as a Toxic Retinopathy in a Case After Scleral-Fixed Intraocular Lens Implantation

Suleyman Ciftcia, d, Ali Simsekb, Leyla Ciftcic

aDepartment of Ophthalmology, Diyarbakır Training and Research Hospital, Diyarbakir, Turkey
bDepartment of Ophthalmology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey
cDepartment of Cardiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
dCorresponding author: Suleyman Ciftci, Diyarbakir Egitim ve Arastirma Hastanesi Goz Hastaliklari Poliklinigi, 21000-Diyarbakir, Turkey

Manuscript accepted for publication November 16, 2012
Short title: Toxic Retinopathy
doi: https://doi.org/10.4021/jmc971w


To report a complication similar a toxic retinopathy. The eye is aphakia due to trauma. The patient is a 70-year-old man. The anesthesia was applied as topically, with subtenon enjection. Two percent sodium hyaluronate (Protectalon 2%) was used as viscoelastic and for endophthalmitis prophylaxis sefuroksim aksetil 1 mg/ 0.1 cc was given at the end of operation. The patient complained blindness. Central retinal artery obstruction, central retinal vein occlusion, peripapiller and macular hemorrhage and optic atrophy were observed in fundus examination. After 6 months, corneal haze, especially at the upper side, occurred. It is clear that, this complication is a toxic retinopathy and a result of sequence of events. After all, a case which has resulted to such a complication due a surgery has never been reported previously.

Keywords: Central retinal artery obstruction; Central retinal vein occlusion; Corneal haze; Macular hemorrhage; Pallor of the optic nerve


We report about a complication similar to a toxic retinopathy in a case. The operation is implantation of seconder scleral-fixed intraocular lens. Obstruction of central retinal artery, occlusion of central retinal vein, peripapiller and macular hemorrhage and optic atrophy occurred right after the operation. After 6 months, haze in the upper side of the cornea occurred (Fig. 1).

Figure 1.
Click for large image
Figure 1. Fundus photograph of the eye. a: central retina, b: inferior central retina, c: superior nasal retina, d: superior retina, e: superior temporal retina of the eye, f: corneal photography of the eye two weeks after the operation, g: corneal photography of the eye shows development of haze 6 months after the operation, h: the retina has become invisible 6 months after the operation.
Case Report▴Top 

The patient is a 70-year-old man. He does not have any disease such as diabetes mellitus or hypertension. Two years ago the patient had an accident by cow horn backlash and underwent limbocorneal suturation and anterior vitrectomy in the primer surgery and the surgery resulted in aphakia. The eye was not vitrectomised but the patient lost a large amount of vitreus during perforation. Fundoscopic examination showed normal retina and pre-operative visual acuity of the patient in the operated eye with pinholl was 0.6.

The anesthesia was applied topically with subtenon enjection and intracameral plain lidocaine was given towards the end of surgery. Two percent sodium hyaluronate was used as viscoelastic and sefuroksim aksetil was injected to anterior chamber for endophthalmitis prophylaxis. Intraocular pressure rose up to about 50 mmHg, 8 hours after operation antiglaucomatous drugs were given. Corneal edema was cleared in two weeks but the patient complained from blindness and defined only light perception. Central retinal artery obstruction, central retinal vein occlusion, peripapiller and macular hemorrhage and optic atrophy were observed in the fundus examination. This complication was not an intraocular infection because the media was clear and there was not redness or pain. After 6 months, corneal haze, especially on the upper side, occurred and the retina has become invisible. Thus, further examination such as fluorescein angiography failed due to corneal haze (Fig. 1h). This complication is similar to hemorrhagic infarction of the retina.


The cause of this complication may be viscoelastic agents, due to the injection of lidocaine into the anterior chamber or cefuroxime. The most important postoperative complication of viscoelastic agents is elevation of intraocular pressure. Increase in intraocular pressure is dose-related and of a transient nature, generally within the first 6 - 24 hours after surgery and typically resolved within 72 hours. Increased intraocular pressure may cause central retinal vein occlusion or central retinal artery obstruction [1, 2]. But the complication occurring in this patient was more serious than complications due to elevated intraocular pressure.

One of the other suspected substances is lidocaine. Hoffman and Fine reported transient amaurosis cases due to intracameral lidocaine [3]. Lincoff H and others reported retinal toxicity after injection of lidocain intraocularly [4]. Liang C reported electroretinogram changes in the rabbit retina but he did not observe any histologic abnormalities after injection of lidocaine hydrochloride intravitreally [5]. All the reported toxicities related to lidocaine do not cause permanent blindness whereas retinal toxicity in this case caused permanent blindness.

The most suspected substance is cefuroxime but there was not major evidence in the literature to prove so. Delyfer MN noted intracameral injection of high doses induced anterior and posterior inflammation [6]. Conversely, Sakarya Y and Sakarya R reported inadvertent intracameral (3 mg in 0.1 ml) cefuroxime injection did not cause any detectable adverse effect on ocular tissues [7].

Research for possible side effects of intracameral lidocaine, viscoelastic agents and intracameral cefuroxime were made in Medline and a few side effects were found. But these complications are not similar by the complication that we reported. Two percent sodium hyaluronate, intracameral lidocaine and cefuroxime have been used for many years and are unlikely to be the cause of the findings. The retinal hemorrages may be related to a vascular event or other pathology anytime from surgery to two weeks post-op, but this patient complained of blindness immediately after surgery and a rapidly atrophy of optic disc is not a usual presentation of vascular event. Retinal hemorrhage in this patient confined in the central, but central retinal vein, occlusion makes widespread retinal hemorrhage and visual deterioration at the level of light perception is required a much more intense bleeding.

We cannot find any related results between the above-mentioned substance and the complication, however and without any doubt it developed as a whole as a result of the surgery. Overall it is clear this complication is a toxic retinopathy and a result of sequence of events resulted by hemorrhagic retinal infarct. The development of corneal haze after hemorrhagic retinal infarct reinforces the idea that these complications are as result of toxicity. We think this toxicity was caused from an ingredient of the drugs or using of excess dose than the recommended dose of any drug during the operation accidentally. After all, a case which has resulted to such a complication in a surgery has never been reported previously, thus we wanted to point it out.



Competing Interests

The authors declare that they have no competing interests.

  1. Lane SS. Viscoelastic Agents: Physical Characteristics and Clinical Applications. Chapter 9. In: William Tasman, eds. Duane's Clinical Ophthalmology on CD-ROM. 1st ed. Philadelphia: Lippincott Williams & Wilkins, 2006.
  2. Radius RL, Finkelstein D. Central retinal artery occlusion (reversible in sickle trait with glaucoma. Br J Ophthalmol. 1976;60(6):428-430.
  3. Hoffman RS, Fine IH. Transient no light perception visual acuity after intracameral lidocaine injection. J Cataract Refract Surg. 1997;23(6):957-958.
  4. Lincoff H, Zweifach P, Brodie S, Fuchs W, Gross S, Kornmehl E, Krauss M, et al. Intraocular injection of lidocaine. Ophthalmology. 1985;92(11):1587-1591.
  5. Liang C, Peyman GA, Sun G. Toxicity of intraocular lidocaine and bupivacaine. Am J Ophthalmol. 1998;125(2):191-196.
  6. Delyfer MN, Rougier MB, Leoni S, Zhang Q, Dalbon F, Colin J, Korobelnik JF. Ocular toxicity after intracameral injection of very high doses of cefuroxime during cataract surgery. J Cataract Refract Surg. 2011;37(2):271-278.
    doi pubmed
  7. Sakarya Y, Sakarya R. Cefuroxime dilution error. Eur J Ophthalmol. 2010;20(2):460-461.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Journal of Medical Cases is published by Elmer Press Inc.


Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.