Cinacalcet and Acute Heart Failure on Dialysis - A New Association

Suzanne H Forbes, Dhakshinamurthy Vijay Anand, R. Andrew Archibald, Neil Ashman


Secondary hyperparathyroidism (SHPT) is common in end stage renal disease and is associated with abnormal bone and mineral metabolism, vascular calcification, bone fracture and increased cardiovascular risk. Cinacalcet is an increasingly widely-used calcimimetic agent for the control of SHPT in such patients and trial data has confirmed its use as an efficacious strategy in achieving target parathyroid hormone (PTH) targets. Here we describe a previously undocumented side-effect of cinacalcet treatment in a man on haemodialysis who developed a new and severe dilated cardiomyopathy in clear association with starting cinacalcet. This subsequently resolved fully after withdrawal of the drug. This case, we believe, is the first documented case of severe left ventricular systolic dysfunction temporally associated with cinacalcet use.

J Med Cases. 2013;4(6):389-392


Cinacalcet; Secondary hyperparathyroidism; Dilated cardiomyopathy; Left ventricular systolic dysfunction; Haemodialysis

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.