Minoxidil Associated Pericardial Effusion: A Case Report

Steven B. Deutsch, Michael Berlowitz


Minoxidil is an antihypertensive that works by directly dilating peripheral vessels. The agent produces vasodilation via a cyclic AMP-mediated effect on arteriolar smooth muscle, with little effect on veins. There have been associations with its use and cause and/or exacerbation of pericardial effusions. This reported adverse effect resulted in a black box warning in the US, which states that minoxidil may cause pericarditis and pericardial effusion that may progress to tamponade. Specifically, patients with renal impairment not on dialysis and individuals with congestive heart failure are reported at higher risk. Here we report a case of a patient with underlying renal disease who presented to the hospital with hypertensive urgency. He developed a pericardial effusion soon after restarting minoxidil, which did not resolve until this medication was discontinued, despite undergoing a pericardial window.

J Med Cases. 2015;6(2):65-67
doi: http://dx.doi.org/10.14740/jmc1928w


Pericardial effusion; Effusion; Antihypertensive; Minoxidil

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Medical Cases, monthly, ISSN 1923-4155 (print), 1923-4163 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.journalmc.org   editorial contact: editor@journalmc.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.