Nuclear Protein of the Testis Midline Carcinoma

Ilda Coelho, Ana Antunes, Catia Cabral, Gloria Abreu, Guilherme Gomes


Nuclear protein in testis (NUT) carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangement that involve the gene encoding the NUT. This carcinoma was recognized in the thymus in 2004 WHO classification as a carcinoma with t(15;19) translocation, and it is also referred to as NUT carcinoma. However, currently, there is still sparse information about this entity which is treated as a very aggressive carcinoma with a median survival of 7 months. We report a case of a 20-year-old man with an aggressive growing pulmonary mass in the upper left lobe associated with bone metastasis. The bronchial and bones metastases biopsies presented a basaloid squamous cell carcinoma, which precipitated the examination for translocation t(15:19) and immunocytochemical study, both presenting positive results, which allowed establishing the diagnosis of NUT carcinoma.

J Med Cases. 2018;9(3):86-89


Nuclear protein in testis; Aggressive carcinomas; t(15;19) translocation

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