Acquired Hemophilia A After SARS-CoV-2 Infection: A Case Report

Jennifer Nardella, Domenico Comitangelo, Renato Marino, Giuseppe Malcangi, Marco Damiano Barratta, Carlo Sabba, Antonio Perrone


Acquired hemophilia A is a rare autoimmune coagulation disorder associated to the development of neutralizing antibodies directed towards coagulation factor VIII, known as factor VIII inhibitors, in subjects with previous normal clotting system homeostasis and personal and family history negative for bleeding episodes. This condition, although variable in severity and clinical presentation, may lead to severe and life-threatening hemorrhages which can be either spontaneous or associated with traumatic events and invasive procedures. Here we report the case of a 53-year-old woman who was admitted to our Internal Medicine Unit Cesare Frugoni, Policlinico di Bari, in July 2021, and diagnosed with acquired hemophilia A. We aim to raise awareness about this rare condition, its clinical presentation and therapeutic management options in order to obtain a quick diagnosis and an effective therapeutic intervention.

J Med Cases. 2022;13(5):197-201


Acquired hemophilia A; SARS-CoV-2; Rituximab; Recombinant porcine factor VIII; Activated prothrombin complex concentrate

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