Skeletal Langerhans Cell Histiocytosis Presenting After Periodontal Disease and Diabetes Insipidus: A Case Report

John D Smith, Daniel E Porter, James S Huntley


Langerhans Cell Histiocytosis (LCH) is a rare condition with extreme clinical variability in terms of presentation, progression and outcomes. A case is described in which Diabetes Insipidus (DI) and periodontal disease preceded the development of a lesion of the temporal bone. Central DI in the child or young adult should prompt an extracranial survey for possible LCH. Periodontal disease has a marked association with LCH, so when DI and periodontal disease co-exist, the index of suspicion for LCH should be raised.

J Med Cases. 2012;3(3):161-163


Langerhans cell histiocytosis; Diabetes insipidus; Periodontal disease

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